Deoxynivalenol and its toxicity

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Deoxynivalenol and its toxicity

Deoxynivalenol (DON) is one of several mycotoxins produced by certain Fusarium species that frequently infect corn, wheat, oats, barley, rice, and other grains in the field or during storage. The exposure risk to human is directly through foods of plant origin (cereal grains) or indirectly through foods of animal origin (kidney, liver, milk, eggs). It has been detected in buckwheat, popcorn, so...

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Occurrence of deoxynivalenol and its major conjugate, deoxynivalenol-3-glucoside, in beer and some brewing intermediates.

Since deoxynivalenol (DON), the main representative of Fusarium toxic secondary metabolites, is a relatively common natural contaminant in barley, its traces can be detected in many commercial beers. Our previous study reporting for the first time the occurrence of relatively high levels of DON-3-glucoside (DON-3-Glc) in malt and beer prepared from relatively "clean" barley (semiscale experimen...

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Low Toxicity of Deoxynivalenol-3-Glucoside in Microbial Cells

Host plants excrete a glucosylation enzyme onto the plant surface that changes mycotoxins derived from fungal secondary metabolites to glucosylated products. Deoxynivalenol-3-glucoside (DON3G) is synthesized by grain uridine diphosphate-glucosyltransferase, and is found worldwide, although information on its toxicity is lacking. Here, we conducted growth tests and DNA microarray analysis to elu...

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Advances in Deoxynivalenol Toxicity Mechanisms: The Brain as a Target

Deoxynivalenol (DON), mainly produced by Fusarium fungi, and also commonly called vomitoxin, is a trichothecene mycotoxin. It is one of the most abundant trichothecenes which contaminate cereals consumed by farm animals and humans. The extent of cereal contamination is strongly associated with rainfall and moisture at the time of flowering and with grain storage conditions. DON consumption may ...

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Phenol and Its Toxicity: A Case Report

Background: Phenol and its derivatives like dinitrophenol and pentachlorophenol (carbolic acid) are widely used as insecticides, but they are very toxic substances. Phenol is a general protoplasmic poison with corrosive local effects that denature proteins. Poisoning with phenol compounds may occur by ingestion, inhalation, and absorption through skin. In this report we presented the toxicity...

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ژورنال

عنوان ژورنال: Interdisciplinary Toxicology

سال: 2010

ISSN: 1337-9569,1337-6853

DOI: 10.2478/v10102-010-0019-x